The first part, "Something's Coming", aired on December 2, 2007.
Felicity Huffman portrayed Lynette Scavo, who fights cancer during the first half of the season and deals with her step-daughter's behavior in the second half.Andrea Bowen portrayed Julie Mayer, the responsible and caring daughter of Susan.Doug Savant portrayed Tom Scavo, Lynette's husband and now owner of a pizzeria.Rachel Fox was promoted to regular after guest starring in several episodes in the previous season as Kayla Huntington Scavo, Tom's mischievous daughter and the result of an affair he had before meeting Lynette.This season featured many established and new guest stars.All eleven starring actors from the previous season returned for this season.
The series is narrated by Brenda Strong, who portrays the deceased Mary Alice Young, as she observes from beyond the grave the lives of the Wisteria Lane residents and her former best friends.
Perkins as executive producers, is season three writer and co-executive producer Bob Daily, whose previous work include sitcoms Frasier and Out of Practice, as well as cartoon series Rugrats.
Keenan will serve as Cherry's second-in-command for the next two years.
Part of Bree's storyline were Shirley Knight returning as Phyllis Van de Kamp, Bree's first mother-in-law, and Dakin Matthews appearing as Reverend Sykes, reverend at the local Presbyterian church.
Part of Gabrielle's storyline were John Slattery playing Victor Lang, Gabrielle's new husband and the mayor of Fairview, Mike Farrell in the role of Milton Lang, Victor's father, Jeff Doucette portraying Father Crowley, priest at the local Catholic church, Justine Bateman playing Ellie Leonard, a drug dealer who rents a room in the Solises' house, and Jesse Metcalfe reappearing as John Rowland, Gabrielle's ex-lover and former gardener.
The fourth season of Desperate Housewives, an American television series created by Marc Cherry, premiered on September 30, 2007 on ABC.