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No previous study has ever analyzed anywhere near that many markers."This study is unique in using a particular technology called a single nucleotide polymorphism, or SNP, genotyping chip; these chips interrogate the nucleotides at 48,000 locations in the genome," said John Novembre, UCLA assistant professor of ecology and evolutionary biology and a member of UCLA's Interdepartmental Program in Bioinformatics.
El músico se ha centrado en su nuevo trabajo discográfico (huye de los eventos y de los focos), pero sigue mostrándose muy generoso con la madre de sus hijos."We were able to study a broader sampling of wolves globally than has ever been done before, including Middle Eastern wolves," said the paper's lead author, Bridgett von Holdt, a UCLA graduate student of ecology and evolutionary biology in Wayne's laboratory who studies the genetics of dog domestication."In our analysis of the entire genome, we found that dogs share more unique markers with Middle Eastern wolves than with East Asian wolves.Our findings strongly contradict the conclusions based on earlier mitochondrial DNA sequence data.""We sampled both groups, the modern explosion of dog breeds and some of the ancient lineages," he said."Our data were aimed at resolving questions about the origin of domestic dogs, the evolution of dog breeds, and the history of dog breeds and relationships to their closest wild progenitor, the gray wolf."The first dogs that appeared in the Middle Eastern archaeological record date back some 12,000 to 13,000 years, Wayne said.Co-authors on the Nature paper include a group of researchers from the National Institutes of Health/National Human Genome Research Institute led by Elaine Ostrander; a group led by Carlos Bustamante, formerly of the Cornell University Department of Biological Statistics and Computational Biology and now a professor of genetics at the Stanford University School of Medicine; and scientists from China, Israel, Australia, Europe and Canada.
UCLA co-authors include Eunjung Han, a UCLA graduate student of Novembre's in biostatistics; John Pollinger, director of UCLA's Conservation Genetics Resource Center and associate director of the Center for Tropical Research at UCLA's Institute of the Environment; and James Knowles, a graduate student from Canada's University of Alberta working in Wayne's laboratory.
We used a genome-wide approach, which avoids the bias of single genome region."The biologists report genetic data from more than 900 dogs from 85 breeds (including all the major ones) and more than 200 wild gray wolves (the ancestor of domestic dogs) worldwide, including populations from North America, Europe, the Middle East and East Asia.
They used molecular genetic techniques to analyze more than 48,000 genetic markers.
"Their integration of genomic data with bioinformatic approaches illustrates how integration has enhanced our ability to analyze biological systems.
Integration of knowledge is changing how we think about how life works.
A dog from Belgium dates back 31,000 years, and a group of dogs from Western Russia is approximately 15,000 years old, Wayne said."We know that dogs from the Middle East were closely associated with humans because they were found in ancient human burial sites," Wayne said.